If you are using WindowsXP you can easily reassign drive letters, but I would hesitate to reassign the boot partition. Windows might not like that, but I've never tried it before
There are many ways to do it, but here is the quickest and most straight forward way I know.
Right-click "My Computer" on your desktop and choose "Manage" from the resulting menu. In the new window that pops up the second item down is "Storage." Under that entry select "Disk Management." That will show you all the drives on your system. You may have an external drive, CD drive or a media card reader that is taking up your drive letters. I've had that problem before Right-click on the partition you wish to change and choose "Change drive letters and paths..."
Hope this helps